Het optreden van hypoglykemie hangt samen met zowel cardiale als niet-cardiale sterfte bij mensen...
Verdieping
EASD 2017 – Genetica van type 1 diabetes
Thomas et al. De belangrijkste genetische determinanten van Type 1 diabetes zijn de HLA-DR3 en HLA...
Updates
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes
The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms
Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance
Statement of Retraction. Iria Nieto-Vazquez, Sonia Fernandez-Veledo, Cristina de Alvaro, and Margarita Lorenzo. Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle. Diabetes 2008;57:3211-3221. https://doi.org/10.2337/db07-1062
Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome
Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation
Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation
Issues and Events
Sex differences in cardiometabolic risk factors, pharmacological treatment and risk factor control in type 2 diabetes: findings from the Dutch ... Diabetes Pearl cohort. https://drc.bmj.com/content/8/1/e001365
Once-weekly insulin icodec has similar glucose-lowering efficacy & safety profile to once-daily insulin glargine U100 in T2 diabetes
Paper ... online
#EASD2020
https://www.nejm.org/doi/full/10.1056/NEJMoa2022474
As I warm up for the #EASD2020 a salient reminder of the ⤵️ life expectancy people with #type1diabetes & #type2diabetes face.
Data from the ... 🇬🇧 @DiabetesAudit & @ONS
Women lose more years than men
- T1D ♀️⤵️ 8.5 yrs
- T1D ♂️⤵️ 7.5 yrs
- T2D ♀️⤵️ 2.0 yrs
- T2D ♂️⤵️ 1.4 yrs
Effects of once-weekly subcutaneous #semaglutide on #kidney function and safety in patients with type 2 #diabetes: a post-hoc analysis of the #SUSTAIN... 1–7 randomised controlled trials https://bit.ly/2Hmch1c #T2D #EASD2020