The International Diabetes Federation reported 6.7 million deaths worldwide among adults with diabetes in 2021, accounting for 12.2% of all deaths globally (1). The age-standardized mortality from diabetes declined from 2007 to 2014 and then stabilized from 2014 to 2017 in the U.S. (2). Recently, U.S. data from National Vital Statistics System demonstrated an increase in deaths with diabetes as the underlying cause of death during the coronavirus disease 2019 (COVID-19) pandemic in most states (3). Diabetes being reported as an underlying cause of death is insufficient to estimate diabetes-related national mortality. In individuals with diabetes during the COVID-19 pandemic, the underlying cause of death may include COVID-19, cardiovascular disease (CVD), cancer, and renal disease. Therefore, we estimated the trends in all-cause diabetes-related mortality and cause-specific mortality in the U.S. before and during the COVID-19 pandemic.
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