Response to Comment on Fahrmann et al. Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2021;44;2132–2139

4 maart 2022
door American Diabetes Association - Care

We thank Dr. González-Clemente et al. (1) for their comments on our article (2). We showed that in the young cohort with type 1 diabetes (T1D) of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study without baseline macrovascular complications, the adverse effect of severe hypoglycemia (SH) history on the cardiovascular system increased with increasing microvascular severity. We have not investigated whether a dose-response relationship exists because of differences in severe hypoglycemia ascertainment in the combined DCCT/EDIC period (2,3). Our results demonstrate that the association between SH and ischemic heart disease (IHD) is of a complicated nature. We showed evidence that this association is multifactorial.

Bekijk het originele bericht

Response to Comment on Fahrmann et al. Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2021;44;2132–2139

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