Diabetic neuropathic pain is associated with elevated plasma levels of methylglyoxal (MGO). MGO is a metabolite of...
Auteur - American Diabetes Association - Diabetes
CD40 Induces Unfolded Protein Response, Upregulation of VEGF, and...
The unfolded protein response (UPR) drives events that promote diabetic retinopathy, including vascular endothelial growth...
Padi4-Dependent NETosis Enables Diet-Induced Gut Hyperpermeability...
Microbial signals trigger the release of neutrophil extracellular traps (NETs) through peptidyl arginine deiminase 4 (PADI4)...
Differential Effects of Retinol-Binding Protein 3 and Anti-VEGF...
Anti–vascular endothelial growth factor (anti-VEGF) therapies are effective treatment for severe diabetic retinopathy (DR)...
Comparison of the Effects of SGLT-2i Versus GLP-1RA on Cardiovascular...
Finding no head-to-head research evaluating the cardiovascular and renal benefits of sodium–glucose cotransporter 2...
Canagliflozin-Induced Adaptive Metabolism in Bone
Sodium–glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of...
Lrtm1: A Novel Sensor of Insulin Signaling and Regulator of...
Insulin regulates glucose uptake and metabolism in muscle via the insulin receptor. Here, we show that Lrtm1 (leucine-rich...
Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose...
Glucolipotoxicity, caused by combined hyperglycemia and hyperlipidemia, results in β-cell failure and type 2 diabetes via...
Deubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing...
Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the...
New Model of Experimental Diabetic Cardiomyopathy Using Combination...
Diabetes leads to a more rapid development of diabetic cardiomyopathy (dbCM) and progression to heart failure in women than...