Distinct Dimensions of Depression Are Associated With Different Brain-Related Biomarkers

Management of depression, a potentially modifiable risk factor for dementia, is of significant importance in elderly with type 2 diabetes (T2D), specifically because of their higher risk for depression and for dementia. We recently published in Diabetes Care evidence showing that in older adults (aged ≥65 years) with T2D participating in the Israel Diabetes and Cognitive Decline (IDCD) study, different dimensions of depression were associated with distinct patterns of cognitive outcomes. Specifically, apathy, but not other depression dimensions, was associated with faster decline in executive functions (1).

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