[Comment] Odanacatib: the best osteoporosis treatment we never had?

Current drugs used to treat osteoporosis target bone turnover. Oestrogens and oestrogen-receptor modulators in post-menopausal women, and bisphosphonates and denosumab in both sexes, all decrease bone resorption, and anabolic drugs such as teriparatide increase bone formation. However, the outcome of treatment with these drugs is affected by coupling of bone turnover; ie, decreased resorption also results in less bone formation and increased formation is associated with increased resorption. Odanacatib, a selective cathepsin-K inhibitor, can uncouple bone turnover so that bone resorption is reduced without substantially inhibiting bone formation.

Bekijk het originele bericht