[Clinical Picture] Denosumab salvage therapy in a patient with a locally advanced and refractory sellar giant cell tumour of bone

A 41-year-old man presented with a 2-month history of progressive vision loss and headaches. MRI revealed a large sellar tumour with suprasellar extension, which was deemed a probable pituitary macroadenoma (figure A, B). The patient underwent transsphenoidal surgery because of visual field defects and headaches. Histological analysis after surgery revealed a giant cell tumour of bone (GCTB) and symptoms improved; however, 2 months later the large sellar–clival remnant compressing the optic chiasm (figure C, D) motivated a second surgery by pterional craniotomy.

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